Publication details. Adam Auton, Genetic predictors of GLP-1 receptor agonist weight loss and side effects, Nature (2026).
The genetics of GLP-1 side effects. If you've experienced nausea or vomiting on a GLP-1 medication, you might have wondered if it means the drug is "working." According to this research, there may be some truth to this theory.

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Genetic Score Also Predicts Weight Loss Efficacy. The CTSGRS score has previously been linked to the effectiveness of GLP-1RA treatment. Prior research cited in the paper indicated that a low CTSGRS score is associated with a two-fold greater weight loss with liraglutide treatment.

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Genetic predictors of GLP1 receptor agonist weight loss and side effects.23andMe finds genetic changes appear to help predict response to GLP-1 drugs for weight loss.