Acetaminophen Daily Dosage During Pregnancy

"Public advisory: Acetaminophen is a recommended treatment for fever and pain during pregnancy". Health Canada, Government of Canada."Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults". Cochrane Database Syst Rev.

While more than two decades of research has shown that acetaminophen is safe to use during pregnancy in consultation with your physician, misinformation about acetaminophen use in pregnancy is growing.

The American College of Obstetricians and Gynecologists and other medical experts consider acetaminophen acceptably safe when taken as directed, and continue to recommend acetaminophen during pregnancy if needed.

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Detailed Acetaminophen dosage information for adults and children. Includes dosages for Pain and Fever; plus renal, liver and dialysis adjustments.

The maximum daily dose of acetaminophen for a healthy adult who weighs at least 150 pounds is 4,000 milligrams (mg).

Standard dosing of acetaminophen during pregnancy is 650 mg every 6 hours or 975 mg every 8 hours, not exceeding 4 g per day 1. Due to concerns about hepatic toxicity, consider limiting chronic administration to 3 g or less per day 2.

Prolonged use of acetaminophen/codeine during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated, and requires management according to protocols developed by neonatology experts.

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Furthermore, the dosage and frequency of acetaminophen use were unknown, as were the specific weeks during pregnancy when acetaminophen was taken. The study authors say that future research could assess these variables through daily diaries.