In mice, edited B lymphocytes derived from transplanted HSPCs were activated by cognate antigen, underwent clonal expansion, and developed into specific antibody-synthesizing or cargo protein-synthesizing plasma cells.
Harald Hartweger, B lymphocyte protein factories produced by hematopoietic stem cell gene editing, Science (2026).Human stem cells edited similarly produced functional immune cells, supporting feasibility for clinical translation.
A researcher is studying cells produced by hematopoietic stem cells. One of the cells that is being studied is a lymphocyte that has CD3 and CD8 receptors on its surface. This type of cell originates from the bone marrow.
B lymphocyte protein factories produced by hematopoietic stem cell gene editing.In this study, we report on an alternative gene editing approach using small numbers of hematopoietic stem and progenitor cells (HSPCs) to direct long-term...
PMID: 41557505. B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.Hartweger H, Ruprecht C, Yao KH, Laffont P, Lima Dos Reis G, Zhou P, Hgglf T, Binet L, Loewe M, Hong JP, Xiao T, Sefik E, Hernandez B, Gazumyan A, Jankovic M...
This particular example perfectly highlights why B Lymphocyte Protein Factories Produced By Hematopoietic Stem Cell Gene is so captivating.
2020. B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.
2026. B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing.. bioRxiv. Malvezzi M, Zhang H, Towers P, Lyden DC, Marx SO, Pitt GS. 2026. FGF13 is not secreted from mouse neurons..
